The vast majority of the time, yes.
Coated sets and NYXL series have different plains steels than the regular XL series. The product pages list the item number for the singles within each set.
For example, the PL010 single is listed in this Chromes 10 gauge set:
The same item number, PL010, is also listed in the Pro Steels 10 gauge set:
This is true for acoustic sets as well. You’ll even find the same plain steel string item number, PL010, in acoustic sets.